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*Correspondence: Juan Carlos Alvarado [email protected] Specialty section: This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The dynamic balance between DNA methyltransferases and TET enzymes functions as a critical regulatory axis, shifting astrocyte gene expression profiles from homeostatic maintenance toward neuroinflammation and neurodegeneration-promoting states

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